She has told the England and Wales Cricket Board (ECB) that she will not be seeking a contract extension.

During her time in charge, England reached the semi-finals of the 2020 Women's T20 World Cup and the final of the 2022 Women's World Cup.

Her last series will be September's visit of India.

Keightley, who took over from Mark Robinson, played nine Tests and 82 one-day internationals for her country and was the first woman to score an ODI century at Lord's.

Prior to taking the England job she was head coach of the Perth Scorchers in the Women's Big Bash League in Australia.

The ECB will now start the recruitment process for her replacement before February's T20 World Cup in South Africa.

"We are incredibly grateful for the commitment and passion Lisa has shown over the last two and a half years in the role," said the ECB's director of women's cricket Jonathan Finch.

"We have seen increased competition for places over the last 12 months and the squad Lisa leaves is an exciting blend of youth and experience.

"Leading an international team is challenging at the best of times. It is more challenging during a pandemic, and Lisa has been able to continue the development of the team during what has been the toughest period we have faced off the field."

Interim ECB chief executive Clare Connor added: "Lisa was always a fierce opponent when she represented Australia, and she's brought that same pride, passion and will to win into everything she's done with the England team.

"The team have enjoyed working with her immensely and I know they'll join me in wishing her all the very best for her next challenge."